MRP-1/CD9 gene transduction downregulates Wnt signal pathways
نویسندگان
چکیده
منابع مشابه
Engineering Signal Transduction Pathways
Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications. In this review, we discuss the challenges associated with engineering signal transduction pathways. Furthermore, we address advant...
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Metallothioneins are small, cysteine-rich, metal-binding proteins that play important roles in maintaining intracellular metal homeostasis and in transition metal detoxification. MTF-1 (metal transcription factor-1) plays a central role in regulating the metal-inducible, transcriptional activation of metallothionein. Here we report that the phosphorylation of MTF-1 plays a critical role in the ...
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Signal transduction is about how molecular mechanisms in cells are used to receive, process and respond to signals from outside and inside of the cell. The term signal is defined in a dual way in this context: being the molecular state of a molecule, e.g. a protein, and at the same time an abstract logical state (active/inactive). This thesis focuses on intracellular signalling: i.e. receiving ...
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Mutant screens have identified several genes in tomato, barley and Arabidopsis that are required for the function of specific plant disease resistance (R) genes. Two of these genes, NDR1 and EDS1, have recently been cloned from Arabidopsis. Most Arabidopsis R genes require NDR1 or EDS1, but not both. In a complementary approach, yeast two-hybrid screens have identified several proteins in tomat...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2004
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1208063